Expression by Ascofuranone, an Isoprenoid Antibiotic, through Downregulation of c-Myc
نویسندگان
چکیده
Authors' A Departmen Medicine a Kyungpook Yeungnam Research Research I Correspon Catholic U 4-Dong, Na 53-650-484
منابع مشابه
p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc.
Ascofuranone has been shown to have antitumor activity, but the precise molecular mechanism by which it inhibits the proliferation of cancer cells remains unclear. Here, we study the effects of ascofuranone on cell cycle progression in human cancer cells and find that ascofuranone induces G(1) arrest without cytoxicity with upregulation of p53 and p21(WAF1/CIP1) while downregulating c-Myc and G...
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Background and aim: Cytokines are a large family of protein messengers. These proteins induce various cellular responses. Janus kinases (JAKs) are mediators of cytokine, activated JAKs phosphorylate signal transducers, and activators of transcription (STAT) proteins that regulate cell differentiation, proliferation, and apoptosis. Aberrant JAK/STAT signaling is involved in the oncogenesis of se...
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Proteomics is a novel molecular profiling technology. It is mainly concerned with determining the structure, expression, localization, biochemical activity, interactions, and cellular roles of any proteins. Clinical research hopes to benefit from proteomics in the identification of new drug targets and the development of new diagnostic markers. Better to understand the mechanisms by which ascof...
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Ascofuranone (AF) showed an antitumor protective effect on L-1210 leukemia when AF was administered once 7 days before tumor challenge. However, effect was not elicited when host mice were treated with AF simultaneously with tumor challenge. AF pretreatment on day 7, 5 and 3 before tumor challenge protected the host from the ascites form of S-180. AF also retarded tumor growth when administered...
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Background Endometriosis is a common gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. This disease affects approximately 10% of women in reproductive age and is associated with pelvic pain, dysmenorrhea and infertility. The theory of involvement of stem cells is a considered new hypothesis in etiology of endometriosis.The aim of this study wa...
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تاریخ انتشار 2010